Tert-butyl 7-(cyanomethyl)indole-1-carboxylate

Tert-butyl 7-(cyanomethyl)indole-1-carboxylate - Names and Identifiers

Name	1H-Indole-1-carboxylic acid, 7-(cyanoMethyl)-, 1,1-diMethylethyl ester
Synonyms	1-Boc-7-(cyanoMethyl)indole Tert-butyl 7-(cyanomethyl)indole-1-carboxylate 1H-Indole-1-carboxylic acid, 7-(cyanoMethyl)-, 1,1-diMethylethyl ester
CAS	597544-18-8

Tert-butyl 7-(cyanomethyl)indole-1-carboxylate - Physico-chemical Properties

Molecular Formula	C15H16N2O2
Molar Mass	256.3
Storage Condition	2-8°C

Tert-butyl 7-(cyanomethyl)indole-1-carboxylate - Introduction

1H-Indole-1-carboxylic acid, 7-(cyanoMethyl)-, 1,1-diMethylethyl ester is an organic compound with the chemical formula C17H20N2O2 and a molecular weight of 292.35g/mol. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: 1H-Indole-1-carboxylic acid, 7-(cyanoMethyl)-, 1,1-diMethyl ester is a white to off-white solid.
-Melting point: about 86-88°C.
-Solubility: Soluble in some organic solvents, such as dimethyl sulfoxide (DMSO), dichloromethane, etc.

Use:
- 1H-Indole-1-carboxylic acid, 7-(cyanoMethyl)-, 1,1-diMethylethyl ester is commonly used as an important intermediate in drug synthesis and organic synthesis, and can be used to synthesize indole compounds.
-Indole compounds have a wide range of applications in the field of medicine, such as anti-cancer drugs, antiviral drugs, antipsychotic drugs, etc.

Preparation Method:
1H-Indole-1-carboxylic acid, 7-(cyanoMethyl)-, 1,1-diMethylethyl ester can be prepared by the following steps:
1. First, 1H-indole -1-carboxylic acid is reacted with N-tert-butylformimide to generate N-Boc-indole -1-formimide.
2. Then, N-Boc-indole -1-carboximide is reacted with cyanomethane in the presence of a base to generate 1H-indole-1-carboxylic acid, 7-(cyanoMethyl)-, 1,1-diMethyl ester.

Safety Information:
- 1H-Indole-1-carboxylic acid, 7-(cyanoMethyl)-, 1,1-diMethylethyl ester's safety data has not been publicly reported, so it is necessary to pay attention to follow the safety operation procedures when using it.
-It may irritate the eyes, skin and respiratory system, so direct contact should be avoided.
-When using and storing, it should be stored in a dry, cool and well-ventilated place, away from fire and other flammable materials.

Please note that 1H-Indole-1-carboxylic acid, 7-(cyanoMethyl)-, 1,1-diMethylethyl ester is a laboratory compound and can only be used under suitable equipment and conditions.

Last Update：2024-04-09 21:01:54